AGER Gene Summary [Human]
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
Details
| Type | Retained Intron |
| Official Symbol | AGER |
| Official Name | advanced glycosylation end-product specific receptor [Source:HGNC Symbol;Acc:HGNC:320] |
| Ensembl ID | ENSG00000204305 |
| Bio databases IDs | |
| Aliases | advanced glycosylation end-product specific receptor, receptor for advanced glycation end-products |
| Synonyms | advanced glycosylation end product-specific receptor, RAGE, SCARJ1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGER often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic and transducing domain
- cytokine binding
- variable domain
- Ig-like C2 domain
- V domain
- identical protein binding
- Ig-like V domain
- cytoplasmic domain
- ligand-binding domain
- Immunoglobulin like
- tail domain
- transmembrane receptor
- protein transduction domain
- extracellular domain
- histone binding
- signaling receptor activity
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- protein binding
- beta-amyloid binding
- DNA binding
- RNA binding
- constant domain
- binding protein
- scavenger receptor
- transmembrane domain
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the AGER gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- benign neoplasia
- cancer
- COVID-19
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- polycystic ovary syndrome
- insulin-dependent diabetes mellitus
- neoplasia
- non-M3 acute myeloid leukemia
- experimental autoimmune encephalomyelitis
role in cell
- expression in
- activation
- signaling in
- binding in
- proliferation
- quantity
- cell death
- apoptosis
- expansion
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- fibrillar center
- cell junction
- cell surface
- Extracellular Space
- postsynaptic region
- cellular membrane
- Nucleus
- intercellular junctions
- apical membrane
- basal membrane
- neurites
- synapse
- sarcolemma
- early endosomes
- late endosomes
- perikaryon
- axons
- plasma
- phagocytic cups
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGER gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of monocyte chemotactic protein-1 production
- negative regulation of long-term synaptic potentiation
- regulation of long-term synaptic potentiation
- negative regulation of interleukin-10 production
- response to wounding
- negative regulation of long term synaptic depression
- cell adhesion
- positive regulation of NF-kappaB transcription factor activity
- learning or memory
- astrocyte activation
- positive regulation of monocyte extravasation
- inflammatory response
- response to hypoxia
- regulation of CD4-positive, alpha-beta T cell activation
- transcytosis
- regulation of synaptic plasticity
- positive regulation of tumor necrosis factor production
- glucose mediated signaling pathway
- positive regulation of chemokine production
- positive regulation of dendritic cell differentiation
- induction of positive chemotaxis
- neuron projection development
- cell surface receptor signaling pathway
- regulation of p38MAPK cascade
- positive regulation of activated T cell proliferation
- positive regulation of p38MAPK cascade
- microglial cell activation
- positive regulation of interleukin-12 production
- positive regulation of JNK cascade
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- positive regulation of heterotypic cell-cell adhesion
- protein localization in membrane
- regulation of inflammatory response
- regulation of T cell mediated cytotoxicity
- positive regulation of interleukin-6 production
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- cell junction
- extracellular region
- apical plasma membrane
- fibrillar center
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- advanced glycation end-product receptor activity
- identical protein binding
- protein binding
- transmembrane signaling receptor activity
- signaling receptor activity
- scavenger receptor activity
- laminin receptor activity
- beta-amyloid binding
- S100 protein binding
- binding, bridging