ABCF1 Gene Summary [Human]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ABCF1 |
| Official Name | ATP binding cassette subfamily F member 1 [Source:HGNC Symbol;Acc:HGNC:70] |
| Ensembl ID | ENSG00000204574 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily F member 1 |
| Synonyms | ABC27, ABC50, ATP binding cassette subfamily F member 1, ATP-binding cassette, sub-family F member 1, AU041969, D17Wsu166e, GCN20 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ABCF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- FeS assembly ATPase SufC
- proposed F420-0 ABC transporter, ATP-binding protein
- walker type B motif
- translation activator
- phosphonate ABC transporter, ATP-binding protein
- walker type A motif
- ATP binding
- protein binding
- cell division ATP-binding protein FtsE
- heme ABC exporter, ATP-binding protein CcmA
- nucleotide-binding domain
- ATP-binding cassette protein, ChvD family
- ribosome binding
- methyl coenzyme M reductase system, component A2
- phosphonate C-P lyase system protein PhnL
- nickel import ATP-binding protein NikE
- ABC transporter
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ABCF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- translation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- translation factor activity, nucleic acid binding