DHX9 Gene Summary [Human]
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | DHX9 |
| Official Name | DExH-box helicase 9 [Source:HGNC Symbol;Acc:HGNC:2750] |
| Ensembl ID | ENSG00000135829 |
| Bio databases IDs | |
| Aliases | DExH-box helicase 9, NDH II, RNA helicase A, leukophysin, nuclear DNA helicase II |
| Synonyms | Atp dependent DNA helicase ii, DDX9, DExH-box helicase 9, HEL-5, leukophysin, LKP, mHEL-5, MRD75, NDH2, NDHII, RHA, RNA helicase A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHX9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- double-stranded RNA binding motif (DSRM) superfamily
- transcription cofactor
- transcription factor binding
- Helicase conserved C-terminal domain
- RNA helicase
- DNA helicase
- domain of unknown function
- ribonucleoprotein binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- nucleic acid binding
- DEAD/DEAH box helicase
- protein binding
- sequence-specific DNA binding
- nucleoside-triphosphatase
- helicase C-terminal domain
- minimal transactivation domain
- Double-stranded RNA binding motif
- Helicase associated domain (HA2)
- transcription co-activator
- low complexity domain
- ATP-binding domain
- helicase
- nucleoside-triphosphate diphosphatase
- ATP binding
- DNA replication origin binding
- chromatin binding
- enzyme
- ATPase
- nuclear transport domain
- helicase domain
- triplex DNA binding
- double-stranded RNA binding
- ribosome binding
- DUF1605 domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- RGG domain
- mRNA binding
- helicase superfamily c-terminal domain
- enzyme binding
- DNA dependent ATPase
- single-stranded RNA binding
- RNA dependent ATPase
- DNA binding
- RNA binding
- DExH domain
- Helicase associated domain (HA2) Add an annotation
- single-stranded DNA binding
- double-stranded DNA binding
- dsRNA-binding domain
- RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- metastasis
- neoplasia
- epithelial cancer
- epithelial neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- prostate cancer
role in cell
- cell death
- phosphorylation in
- survival
- apoptosis
- expression in
- proliferation
- activation in
- cell viability
- quantity
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear chromatin
- cytoplasmic ribonucleoprotein granule
- ribonucleoprotein granule
- Cytoplasm
- actin cytoskeleton
- centrosome
- actin filaments
- granules
- cytosol
- spliceosomes
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear rim
- nuclear envelope
- PML nuclear bodies
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHX9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of response to cytokine stimulus
- negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- DNA replication
- positive regulation of DNA replication
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of RNA export from nucleus
- positive regulation of interferon-alpha production
- inflammatory response
- DNA duplex unwinding
- positive regulation of interferon-beta production
- alternative nuclear mRNA splicing, via spliceosome
- positive regulation of fibroblast proliferation
- regulation of defense response to virus by host
- pyroptosis
- osteoblast differentiation
- positive regulation of interleukin-18 production
- cellular response to tumor necrosis factor
- positive regulation of tumor necrosis factor production
- small RNA loading onto RISC
- positive regulation of viral transcription
- mRNA transport
- positive regulation of DNA repair
- macromolecular complex assembly
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
- gene silencing by miRNA
- positive regulation of inflammatory response
- transcription termination, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
- cellular response to exogenous dsRNA
- regulation of mRNA processing
- rhythmic process
- positive regulation of cytoplasmic translation
- positive regulation of innate immune response
- innate immune response
- RNA secondary structure unwinding
- regulation of cytoplasmic translation
- positive regulation of interleukin-6 production
- CRD-mediated mRNA stabilization
Cellular Component
Where in the cell the gene product is active
- CRD-mediated mRNA stability complex
- nuclear body
- nucleolus
- intracellular
- nucleoplasm
- nucleus
- nuclear stress granule
- centrosome
- cytoplasm
- perichromatin fibrils
- membrane
- actin cytoskeleton
- RISC-loading complex
- cytosol
- macromolecular complex
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- nucleoside-triphosphate diphosphatase activity
- RNA polymerase II core binding
- single-stranded DNA binding
- regulatory region RNA binding
- RNA polymerase binding
- ATP binding
- DNA replication origin binding
- RNA binding
- RNA helicase activity
- double-stranded RNA binding
- single-stranded RNA binding
- RNA stem-loop binding
- mRNA binding
- 3'-5' DNA/RNA helicase activity
- chromatin DNA binding
- siRNA binding
- 3'-5' DNA helicase activity
- DNA binding
- DNA helicase activity
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- metal ion binding
- ribosome binding
- triplex DNA binding
- nucleoside-triphosphatase activity
- 3'-5' RNA helicase activity