DOK6 Gene Summary [Human]
DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | DOK6 |
| Official Name | docking protein 6 [Source:HGNC Symbol;Acc:HGNC:28301] |
| Ensembl ID | ENSG00000206052 |
| Bio databases IDs | |
| Aliases | docking protein 6 |
| Synonyms | docking protein 6, DOK5L, Hs.278285, HsT3226, RGD1564376 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DOK6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTB domain (IRS-1 type)
- PH domain
- protein binding
- Pleckstrin homology-like domain
Pathways
Biological processes and signaling networks where the DOK6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DOK6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane receptor protein tyrosine kinase signaling pathway
- Ras protein signal transduction
- positive regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding