CLIC1 Gene Summary [Human]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CLIC1 |
| Official Name | chloride intracellular channel 1 [Source:HGNC Symbol;Acc:HGNC:2062] |
| Ensembl ID | ENSG00000206394 |
| Bio databases IDs | |
| Aliases | chloride intracellular channel 1 |
| Synonyms | chloride intracellular channel 1, CL1C1, CLCNL1, Clcp, G6, NCC27, NUCLEAR CHLORIDE ION CHANNEL, RNCC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLIC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- chloride channel
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein binding
- voltage-gated chloride channel
- intracellular chloride channel protein
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- liver cancer
- epithelial cancer
- colorectal cancer
- ovarian cancer
- pervasive developmental disorder
- diabetic retinopathy
- hepatitis B surface antigen-negative hepatitis C virus negative hepatocellular carcinoma
- hepatitis B virus-related hepatocellular carcinoma
- inguinal hernia
role in cell
- aggregation
- proliferation
- expression in
- differentiation
- replication in
- motility
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- membrane fraction
- Cytoplasm
- cell surface
- perinuclear region
- Mitochondria
- basal cell surfaces
- mitochondrial membrane
- nuclear envelope
- brush border
- microvilli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLIC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of mitochondrial membrane potential
- positive regulation of osteoblast differentiation
- platelet aggregation
- chloride transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
- nuclear envelope
- chloride channel complex
- nucleus
- extracellular space
- nuclear membrane
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- brush border
- cytoplasm
- blood microparticle
- mitochondrion
- membrane
- vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- chloride channel activity