SERPINE2 Gene Summary [Human]
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | SERPINE2 |
| Official Name | serpin family E member 2 [Source:HGNC Symbol;Acc:HGNC:8951] |
| Ensembl ID | ENSG00000135919 |
| Bio databases IDs | |
| Aliases | serpin family E member 2, glial-derived nexin 1 |
| Synonyms | B230326M24Rik, CRG, GDN, GDNPF, GDNPN1, GLIA DERIVED NEXIN, NEXIN1, PAI-1, PI-7, PN-1, PNI, PROTEASE NEXIN1, serine (or cysteine) peptidase inhibitor, clade E, member 2, Serpin-4, serpin family E member 2, Spi4, Spin4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINE2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- active site
- protein binding
- receptor binding
- heparin binding
- glycosaminoglycan binding
- Serpin (serine protease inhibitor)
- reactive serpin loop
Pathways
Biological processes and signaling networks where the SERPINE2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- squamous cell lung cancer
- lung squamous cell carcinoma
- epithelial cancer
- cholangiocarcinoma
- cholangiocarcinoma cancer
- pancreatic neoplasm
- pancreatic neoplasia
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- proliferation
- apoptosis
- cell death
- binding
- invasion
- number
- migration
- phosphorylation in
- expression in
- regeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- perinuclear region
- cytosol
- trans Golgi network
- alpha granules
- neuromuscular junctions
- transport vesicles
- extracellular matrix
- membrane processes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINE2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- secretory granule organization
- negative regulation of cell proliferation
- negative regulation of platelet aggregation
- negative regulation of blood coagulation
- innervation
- negative regulation of protein catabolic process
- positive regulation of astrocyte differentiation
- negative regulation of proteolysis
- negative regulation of plasminogen activation
- negative regulation of protein processing
- negative regulation of cell growth
- negative regulation of endopeptidase activity
- long-term synaptic potentiation
- regulation of synaptic transmission, glutamatergic
- platelet activation
- secretion by cell
- detection of mechanical stimulus involved in sensory perception
- mating plug formation
- protein catabolic process
- seminal vesicle epithelium development
- cerebellar granular layer morphogenesis
- negative regulation of smoothened signaling pathway
- regulation of timing of cell differentiation
- cell differentiation
- negative regulation of sodium ion transport
- regulation of cell migration
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- platelet alpha granule
- cytosol
- neuromuscular junction
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- glycosaminoglycan binding
- heparin binding
- receptor binding