SIPA1 Gene Summary [Human]
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SIPA1 |
| Official Name | signal-induced proliferation-associated 1 [Source:HGNC Symbol;Acc:HGNC:10885] |
| Ensembl ID | ENSG00000213445 |
| Bio databases IDs | |
| Aliases | signal-induced proliferation-associated 1 |
| Synonyms | signal-induced proliferation-associated 1, signal-induced proliferation associated gene 1, SPA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIPA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rap/ran-GAP
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- GTPase activator
- protein binding
- PDZ domain
- Cell division protein ZapB
Pathways
Biological processes and signaling networks where the SIPA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- schizophrenia
- anemia
- non-insulin-dependent diabetes mellitus
- hyperplasia
- metabolic syndrome X
- essential hypertension
- coronary artery disease
- psoriatic arthritis
- gastric carcinoma
role in cell
- phosphorylation in
- activation in
- proliferation
- expression in
- differentiation
- quantity
- detachment
- survival
- morphology
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- nuclear fraction
- cytoskeleton
- perinuclear region
- focal adhesions
- cell cortex
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIPA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- negative regulation of cell growth
- signal transduction
- regulation of small GTPase mediated signal transduction
- negative regulation of cell adhesion
- negative regulation of cell cycle
- epithelial cell morphogenesis
- adaptive immune response
- establishment of epithelial cell polarity
- cellular response to water deprivation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- macromolecular complex
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity