Sipa1 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Acts upstream of or within regulation of cell cycle. Predicted to be located in several cellular components, including endomembrane system; nucleus; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; heart; immune system; liver; and lung. Used to study chronic myeloid leukemia. Orthologous to human SIPA1 (signal-induced proliferation-associated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sipa1 |
| Official Name | signal-induced proliferation associated gene 1 [Source:MGI Symbol;Acc:MGI:107576] |
| Ensembl ID | ENSMUSG00000056917 |
| Bio databases IDs | |
| Aliases | signal-induced proliferation associated gene 1 |
| Synonyms | signal-induced proliferation-associated 1, signal-induced proliferation associated gene 1, SPA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sipa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rap/ran-GAP
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- GTPase activator
- protein binding
- PDZ domain
- Cell division protein ZapB
Pathways
Biological processes and signaling networks where the Sipa1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- schizophrenia
- anemia
- non-insulin-dependent diabetes mellitus
- hyperplasia
- metabolic syndrome X
- essential hypertension
- coronary artery disease
- psoriatic arthritis
- gastric carcinoma
role in cell
- phosphorylation in
- activation in
- proliferation
- expression in
- differentiation
- quantity
- detachment
- survival
- morphology
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- nuclear fraction
- cytoskeleton
- perinuclear region
- focal adhesions
- cell cortex
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sipa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- negative regulation of cell growth
- signal transduction
- regulation of small GTPase mediated signal transduction
- negative regulation of cell adhesion
- negative regulation of cell cycle
- epithelial cell morphogenesis
- adaptive immune response
- establishment of epithelial cell polarity
- cellular response to water deprivation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- macromolecular complex
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity