LTB4R Gene Summary [Human]
Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LTB4R |
| Official Name | leukotriene B4 receptor [Source:HGNC Symbol;Acc:HGNC:6713] |
| Ensembl ID | ENSG00000213903 |
| Bio databases IDs | |
| Aliases | leukotriene B4 receptor |
| Synonyms | BLT-1, Blt1r, BLTR, CMKRL1, GPR16, leukotriene B4 receptor, leukotriene B4 receptor 1, LTB4-R1, LTBR1, mBLTR, P2RY7, P2Y7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LTB4R often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- nucleotide binding
- activation core
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- leukotriene receptor
- seven-transmembrane G protein-coupled receptor superfamily
- leukotriene B4 receptor
Pathways
Biological processes and signaling networks where the LTB4R gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- arthritis
- hyperplasia
- thermal hyperalgesia
- COVID-19
- airway hyperresponsiveness
- endometriosis
- eosinophilia
- atherosclerosis
- severe acute respiratory syndrome
- hyperinsulinism
role in cell
- expression in
- phosphorylation in
- proliferation
- motility
- number
- quantity
- transcription in
- degranulation
- activity
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LTB4R gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- neuropeptide signaling pathway
- immune response
- G-protein coupled receptor signaling pathway
- muscle contraction
- phospholipase C-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- leukotriene receptor activity
- G-protein coupled peptide receptor activity
- leukotriene B4 receptor activity