GNAT3 Gene Summary [Human]
Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | GNAT3 |
| Official Name | G protein subunit alpha transducin 3 [Source:HGNC Symbol;Acc:HGNC:22800] |
| Ensembl ID | ENSG00000214415 |
| Bio databases IDs | |
| Aliases | G protein subunit alpha transducin 3 |
| Synonyms | alpha GUSTDUCIN, Galphagust, GDCA, Ggust, G protein subunit alpha transducin 3, G protein subunit α transducin 3, GTN, Gαgust, HG1E, α GUSTDUCIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GNAT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- G protein alpha subunit
- GTPase
- G-protein alpha subunit
- enzyme
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the GNAT3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- axonemes
- lateral cell surfaces
- apical membrane
- plasma membrane projections
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GNAT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of umami taste
- sensory perception of sweet taste
- detection of chemical stimulus involved in sensory perception of bitter taste
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- response to nicotine
Cellular Component
Where in the cell the gene product is active
- heterotrimeric G-protein complex
- cytoplasm
- acrosomal vesicle
- macromolecular complex
- photoreceptor inner segment
- plasma membrane
- axoneme
- apical plasma membrane
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- GTP binding
- G-protein coupled receptor binding
- metal ion binding
- GTPase activity
- G-protein beta/gamma-subunit complex binding