MEG3 Gene Summary [Human]
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | MEG3 |
| Official Name | maternally expressed 3 [Source:HGNC Symbol;Acc:HGNC:14575] |
| Ensembl ID | ENSG00000214548 |
| Bio databases IDs | |
| Aliases | maternally expressed 3, non-protein coding RNA 23, long intergenic non-protein coding RNA 23, gene trap locus 2 |
| Synonyms | 2900016C05Rik, 3110050O07Rik, 6330408G06Rik, D12Bwg1266e, FP504, GTL2, LINC00023, maternally expressed 3, NCRNA00023, onco-lncRNA-83, prebp1, PRO0518, PRO2160 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MEG3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded DNA binding
- protein binding activity, bridging
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- breast cancer
- respiratory failure
- growth failure
- organismal death
- insulin-dependent diabetes mellitus
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- breast carcinoma
- urothelial bladder carcinoma
role in cell
- expression in
- cell viability
- transcription in
- growth
- proliferation
- phosphorylation in
- production in
- morphology
- activation in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MEG3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth
- gene silencing by miRNA
Cellular Component
Where in the cell the gene product is active
- RNA-induced silencing complex