ORM2 Gene Summary [Human]

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
ORM2
Official Name
orosomucoid 2 [Source:HGNC Symbol;Acc:HGNC:8499]
Ensembl ID
ENSG00000228278
Bio databases IDs NCBI: 5005 Ensembl: ENSG00000228278
Aliases orosomucoid 2, alpha-1-acid glycoprotein, type 2
Synonyms AGP2, AGP-B, AGP-B', Alpha 1 acid glycoprotein 1, Alpha1 Acid Glycoprotein B, orosomucoid 2, α 1 acid glycoprotein 1
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ORM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • lipocalin/cytosolic fatty acid-binding protein family
  • protein binding
  • Lipocalin / cytosolic fatty-acid binding protein family

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • chronic fatigue syndrome
  • acute myeloid leukemia
  • Alzheimer disease
  • papillary thyroid carcinoma
  • papillary thyroid cancer
  • Parkinson disease
  • COVID-19
  • mild cognitive impairment
  • osteoporosis
  • endometriosis
regulated by
  • lipopolysaccharide
  • TP53
  • progesterone
  • HIV-1 BaL
  • STX3
  • promethazine
regulates
role in cell
  • production in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • secretory granule lumen
  • azurophil granule lumen
  • alpha granules
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ORM2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of tumor necrosis factor production
  • regulation of immune system process
  • acute-phase response
  • positive regulation of interleukin-1 beta production
  • positive regulation of interleukin-1 production

Cellular Component

Where in the cell the gene product is active
  • platelet alpha granule lumen
  • extracellular space
  • extracellular vesicular exosome
  • specific granule lumen
  • blood microparticle
  • extracellular region
  • azurophil granule lumen

Gene-Specific Assays for Results You Can Trust

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