PTGDS Gene Summary [Human]
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PTGDS |
| Official Name | prostaglandin D2 synthase [Source:HGNC Symbol;Acc:HGNC:9592] |
| Ensembl ID | ENSG00000107317 |
| Bio databases IDs | |
| Aliases | prostaglandin D2 synthase, lipocalin-type prostaglandin D synthase |
| Synonyms | Beta-trace, LIPOCALIN-type PROSTAGLANDIN D SYNTHASE, L-PGDS, PDS, PGD2, PGD2 synthase, PGDS, PGDS2, PH2DISO, prostaglandin D2 synthase, Prostaglandin d2 synthase (brain), Prostaglandin D Synthase, Prostaglandin D synthetase, PROSTAGLANDIN-H2 D-ISOMERASE, Ptgs3, β tp, β-trace |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGDS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipocalin/cytosolic fatty acid-binding protein family
- fatty acid binding
- active site
- enzyme
- protein binding
- retinoid binding
- Lipocalin / cytosolic fatty-acid binding protein family
- prostaglandin-D synthase
Pathways
Biological processes and signaling networks where the PTGDS gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- renal failure
- diabetic nephropathy
- edema
- lupus nephritis
- prostate cancer
- Huntington disease
- impaired glucose tolerance
- osteoarthritis
- passive cutaneous anaphylaxis
role in cell
- apoptosis
- activation in
- phosphorylation in
- damage
- proliferation
- migration
- formation
- size
- differentiation
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Extracellular Space
- apical compartment
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- apical membrane
- nucleoplasm
- outer nuclear membrane
- neurites
- photoreceptor outer segments
- photoreceptor inner segments
- rough endoplasmatic reticulum
- extracellular matrix
- plasma
- interphotoreceptor matrix
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGDS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cyclooxygenase pathway
- regulation of circadian sleep/wake cycle, sleep
- prostaglandin biosynthetic process
- response to glucocorticoid stimulus
- negative regulation of male germ cell proliferation
- gene expression
- mast cell degranulation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- extracellular space
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- rough endoplasmic reticulum
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- prostaglandin-D synthase activity
- fatty acid binding
- protein binding
- retinoid binding