NFAM1 Gene Summary [Human]
The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NFAM1 |
| Official Name | NFAT activating protein with ITAM motif 1 [Source:HGNC Symbol;Acc:HGNC:29872] |
| Ensembl ID | ENSG00000235568 |
| Bio databases IDs | |
| Aliases | NFAT activating protein with ITAM motif 1 |
| Synonyms | 4921501M20RIK, CNAIP, Nfat activating molecule with ITAM motif 1, NFAT activating protein with ITAM motif 1, RGD1308316 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFAM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- Crohn disease
- ulcerative colitis
- spinocerebellar ataxia type 3
role in cell
- expression in
- differentiation
- production in
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- insoluble fractions
- cell surface
- cellular membrane
- secretory granule membrane
- lysosome membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFAM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of B cell receptor signaling pathway
- calcineurin-NFAT signaling cascade
- inflammatory response
- B cell differentiation
- signal transduction
- regulation of B cell differentiation
- positive regulation of cytokine production
- intracellular signal transduction
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane raft
- membrane
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding