TIGIT Gene Summary [Human]
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | TIGIT |
| Official Name | T cell immunoreceptor with Ig and ITIM domains [Source:HGNC Symbol;Acc:HGNC:26838] |
| Ensembl ID | ENSG00000181847 |
| Bio databases IDs | |
| Aliases | T cell immunoreceptor with Ig and ITIM domains |
| Synonyms | Gm607, LOC100047611, RGD1563191, T cell immunoreceptor with Ig and ITIM domains, VSIG9, VSTM3, WUCAM |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TIGIT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- receptor binding
- identical protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cutaneous melanoma
- cancer
- experimental autoimmune encephalomyelitis
- gastroesophageal adenocarcinoma
- lung adenocarcinoma
- squamous cell lung cancer
- metastatic hepatocellular carcinoma
- locally advanced gastric adenocarcinoma
- psoriatic arthritis
role in cell
- proliferation
- migration
- expression in
- production in
- activation
- number
- killing
- killing by
- Th2 immune response
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TIGIT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-12 production
- negative regulation of T cell activation
- positive regulation of interleukin-10 production
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- receptor binding