MINDY2 Gene Summary [Human]
Enables cysteine-type peptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in protein K48-linked deubiquitination. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | MINDY2 |
| Official Name | MINDY lysine 48 deubiquitinase 2 [Source:HGNC Symbol;Acc:HGNC:26954] |
| Ensembl ID | ENSG00000128923 |
| Bio databases IDs | |
| Aliases | MINDY lysine 48 deubiquitinase 2 |
| Synonyms | AI465301, B230380D07Rik, FAM63B, MINDY lysine 48 deubiquitinase 2, mKIAA1164, RGD1311456 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MINDY2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MINDY deubiquitinase
- protein binding
- cysteine-type carboxypeptidase
- transporter
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- major depression
- metastasis
- schizophrenia
- organismal death
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
- pancreatic cancer
role in cell
- proliferation
- expression in
- migration
- invasion by
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MINDY2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- K63-linked polyubiquitin binding
- K11-linked polyubiquitin binding
- cysteine-type carboxypeptidase activity
- K6-linked polyubiquitin binding