ZBED6 Gene Summary [Human]
The protein encoded by this transposon-derived intronless gene is a transcriptional repressor that binds to the consensus sequence 5'-GCTCGC-3'. The encoded protein has been shown to repress IGF2 transcription. This gene is located within the first intron of the ZC3H11A gene. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | ZBED6 |
| Official Name | zinc finger BED-type containing 6 [Source:HGNC Symbol;Acc:HGNC:33273] |
| Ensembl ID | ENSG00000257315 |
| Bio databases IDs | |
| Aliases | zinc finger BED-type containing 6 |
| Synonyms | Gm38394, Gm8466, LOC100909876, LOC685209, MGR, zinc finger BED-type containing 6, zinc finger, BED-type containing 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZBED6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- nucleic acid binding
- BED zinc finger
- hAT family C-terminal dimerization region
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- breast carcinoma
- alopecia
role in cell
- expression in
- growth
- proliferation
- apoptosis
- morphology
- S phase
- S/G2 phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZBED6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of insulin secretion involved in cellular response to glucose stimulus
- negative regulation of muscle cell differentiation
- negative regulation of transcription, DNA-dependent
- blastocyst hatching
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- centriolar satellite
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- transcription regulatory region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity