Gm38394 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of muscle cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within blastocyst hatching. Located in cytoplasm and nucleolus. Is expressed in early conceptus; nervous system; neural retina; and secondary oocyte. Orthologous to human ZBED6 (zinc finger BED-type containing 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gm38394 |
| Official Name | predicted gene, 38394 [Source:MGI Symbol;Acc:MGI:5614057] |
| Ensembl ID | ENSMUSG00000094410 |
| Bio databases IDs | |
| Aliases | predicted gene, 38394 |
| Synonyms | Gm38394, Gm8466, LOC100909876, LOC685209, MGR, zinc finger BED-type containing 6, zinc finger, BED-type containing 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gm38394 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- nucleic acid binding
- BED zinc finger
- hAT family C-terminal dimerization region
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- breast carcinoma
- alopecia
role in cell
- expression in
- growth
- proliferation
- apoptosis
- morphology
- S phase
- S/G2 phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gm38394 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of insulin secretion involved in cellular response to glucose stimulus
- negative regulation of muscle cell differentiation
- negative regulation of transcription, DNA-dependent
- blastocyst hatching
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- centriolar satellite
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- transcription regulatory region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity