APOC4 Gene Summary [Human]
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | APOC4 |
| Official Name | apolipoprotein C4 [Source:HGNC Symbol;Acc:HGNC:611] |
| Ensembl ID | ENSG00000267467 |
| Bio databases IDs | |
| Aliases | apolipoprotein C4 |
| Synonyms | Acl, APO-CIV, Apolipoprotein c2-linked, apolipoprotein C4, apolipoprotein C-IV, LOC686851 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APOC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- protein binding
- Apolipoprotein C4
- transporter
Pathways
Biological processes and signaling networks where the APOC4 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Atherosclerosis Signaling
- Clathrin-mediated Endocytosis Signaling
- FXR/RXR Activation
- IL-12 Signaling and Production in Macrophages
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Maturity Onset Diabetes of Young (MODY) Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human APOC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- positive regulation of sequestering of triglyceride
- lipid metabolic process
- triglyceride homeostasis
Cellular Component
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- high-density lipoprotein particle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipid transporter activity