SRCIN1 Gene Summary [Human]
Enables protein kinase binding activity. Involved in several processes, including regulation of dendritic spine morphogenesis; regulation of protein tyrosine kinase activity; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SRCIN1 |
| Official Name | SRC kinase signaling inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:29506] |
| Ensembl ID | ENSG00000273608 |
| Bio databases IDs | |
| Aliases | SRC kinase signaling inhibitor 1 |
| Synonyms | KIAA1684, mKIAA1684, P140, p140Cap, p140CAS, SNIP, SNIP isoform 1, SRC kinase signaling inhibitor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRCIN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNAP-25 binding domain
- protein kinase binding
- coiled-coil domain
- protein domain specific binding
- protein binding
- charged domain
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast cancer
- thyroid carcinoma
- epithelial thyroid cancer
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
- colon adenocarcinoma
- colon epithelial cancer
role in cell
- phosphorylation in
- migration
- chemotaxis
- proliferation
- stabilization in
- activation in
- adhesion
- quantity
- long-term potentiation
- plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- presynaptic regions
- perinuclear region
- postsynaptic region
- actin cytoskeleton
- actin filaments
- synaptic vesicles
- synaptosomes
- synapse
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRCIN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- positive regulation of protein tyrosine kinase activity
- negative regulation of protein tyrosine kinase activity
- substrate adhesion-dependent cell spreading
- regulation of cell migration
- exocytosis
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- focal adhesion
- cytoplasm
- actin cytoskeleton
- synapse
- axon
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding