TPD52L2 Gene Summary [Human]

This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]

Details

Type
Protein Coding
Official Symbol
TPD52L2
Official Name
TPD52 like 2 [Source:HGNC Symbol;Acc:HGNC:12007]
Ensembl ID
ENSG00000101150
Bio databases IDs NCBI: 7165 Ensembl: ENSG00000101150
Aliases TPD52 like 2
Synonyms 2810411G23RIK, D54, TPD52 like 2, TPD54, tumor protein D52-like 2, tumour protein D52-like 2
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPD52L2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Tumour protein D52 family
  • protein homodimerization
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Huntington disease
regulated by
  • TNF
  • IL4
  • Rpmi 8226 cells
  • PML
  • FN1
  • DAP3
  • IL1B
  • mir-122 (includes others)
  • isobutylmethylxanthine
  • Jurkat E6.1 cells
regulates
role in cell
  • migration
  • invasion by
  • proliferation
  • dispersal
  • dispersal in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pH resistant lipid raft fraction
  • perinuclear region
  • Nucleus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TPD52L2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • carbohydrate metabolic process

Cellular Component

Where in the cell the gene product is active
  • cytoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.