MYO19 Gene Summary [Human]
Enables actin binding activity. Involved in regulation of cytokinesis and regulation of mitochondrial fission. Acts upstream of or within mitochondrion migration along actin filament. Located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MYO19 |
| Official Name | myosin XIX [Source:HGNC Symbol;Acc:HGNC:26234] |
| Ensembl ID | ENSG00000278259 |
| Bio databases IDs | |
| Aliases | myosin XIX |
| Synonyms | 1110055A02Rik, MYOHD1, myosin XIX, RGD1559961 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYO19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- Calmodulin-binding motif
- Myosin and Kinesin motor domain
- actin binding
- microfilament motor protein
- enzyme
- ATPase
- Myosin
- Myosin head (motor domain)
- IQ calmodulin-binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYO19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle transport along actin filament
- regulation of cytokinesis
- actin filament organization
- mitochondrion migration along actin filament
- regulation of mitochondrial fission
Cellular Component
Where in the cell the gene product is active
- myosin complex
- cytoplasm
- mitochondrion
- membrane
- actin cytoskeleton
- vesicle
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATPase activity
- ATP binding
- plus-end directed microfilament motor activity
- actin binding
- microfilament motor activity
- myosin light chain binding