Klf16 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within G protein-coupled dopamine receptor signaling pathway and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; gut; and retina. Orthologous to human KLF16 (KLF transcription factor 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klf16 |
| Official Name | Kruppel-like factor 16 [Source:MGI Symbol;Acc:MGI:2153049] |
| Ensembl ID | ENSMUSG00000035397 |
| Bio databases IDs | |
| Aliases | Kruppel-like factor 16 |
| Synonyms | BTEB4, DRRF, KLF transcription factor 16, Kruppel-like transcription factor 16, LOC664629, LOC686920, NSLP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klf16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- transcription regulator
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc ribbon
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Huntington disease
- Alzheimer disease
role in cell
- expression in
- migration
- invasion by
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klf16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- dopamine receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity