Lrp5 Gene Summary [Mouse]
Enables Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including cell surface receptor signaling pathway; osteoblast development; and positive regulation of osteoblast differentiation. Acts upstream of or within several processes, including embryonic morphogenesis; mammary gland development; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study exudative vitreoretinopathy and osteoporosis-pseudoglioma syndrome. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease (multiple). Orthologous to human LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrp5 |
| Official Name | low density lipoprotein receptor-related protein 5 [Source:MGI Symbol;Acc:MGI:1278315] |
| Ensembl ID | ENSMUSG00000024913 |
| Bio databases IDs | |
| Aliases | low density lipoprotein receptor-related protein 5 |
| Synonyms | BMND1, EVR1, EVR4, HBM, LDL receptor related protein 5, low density lipoprotein receptor-related protein 5, LR3, LRP-7, mKIAA4142, OPPG, OPS, OPTA1, PCLD4, VBCH2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Wnt-protein binding
- Wnt receptor
- Low-density lipoprotein receptor repeat class B
- protein binding
- NHL repeat unit of beta-propeller proteins
- Wnt binding domain
- cytoplasmic domain
- transmembrane domain
- LDLa
- intracellular domain
- cytosolic tail domain
- Low-density lipoprotein-receptor YWTD domain
- transmembrane receptor
- Coagulation Factor Xa inhibitory site
- coreceptor
Pathways
Biological processes and signaling networks where the Lrp5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Molecular Mechanisms of Cancer
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- VDR/RXR Activation
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colon epithelial cancer
- colorectal cancer
- epithelial cancer
- gastrointestinal neoplasia
- endometriosis
- osteoarthritis
- osteoporosis
- osteoporosis-pseudoglioma syndrome
- aortic valve calcification
role in cell
- downregulation in
- accumulation in
- phosphorylation in
- apoptosis
- motility
- expression in
- activation in
- translocation
- differentiation
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion involved in cellular response to glucose stimulus
- retina morphogenesis in camera-type eye
- positive regulation of cell proliferation
- anterior/posterior pattern specification
- bone morphogenesis
- nervous system development
- cholesterol metabolic process
- positive regulation of fat cell differentiation
- positive regulation of mitosis
- positive regulation of osteoblast differentiation
- branching involved in mammary gland duct morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- amino acid transport
- glucose catabolic process
- cholesterol homeostasis
- cell-cell signaling involved in mammary gland development
- bone marrow development
- embryonic digit morphogenesis
- negative regulation of osteoblast differentiation
- positive regulation of transcription, DNA-dependent
- gastrulation with mouth forming second
- somatic stem cell maintenance
- canonical Wnt receptor signaling pathway
- anatomical structure regression
- positive regulation of osteoblast proliferation
- bone remodeling
- mesodermal cell migration
- establishment of blood-brain barrier
- positive regulation of mesenchymal cell proliferation
- regulation of apoptotic process
- osteoblast development
- endocytosis
- regulation of blood pressure
- response to peptide hormone stimulus
- retinal blood vessel morphogenesis
- adipose tissue development
- cell migration involved in gastrulation
- extracellular matrix-cell signaling
- osteoblast proliferation
- gene expression
- negative regulation of protein serine/threonine kinase activity
Cellular Component
Where in the cell the gene product is active
- receptor complex
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- Wnt-activated receptor activity
- protein binding
- Wnt-protein binding
- toxin transporter activity