Lrp5 Gene Summary [Mouse]
Enables Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including cell surface receptor signaling pathway; osteoblast development; and positive regulation of osteoblast differentiation. Acts upstream of or within several processes, including embryonic morphogenesis; mammary gland development; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study exudative vitreoretinopathy and osteoporosis-pseudoglioma syndrome. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease (multiple). Orthologous to human LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrp5 |
| Official Name | low density lipoprotein receptor-related protein 5 [Source:MGI Symbol;Acc:MGI:1278315] |
| Ensembl ID | ENSMUSG00000024913 |
| Bio databases IDs | |
| Aliases | low density lipoprotein receptor-related protein 5 |
| Synonyms | BMND1, EVR1, EVR4, HBM, LDL receptor related protein 5, low density lipoprotein receptor-related protein 5, LR3, LRP-7, mKIAA4142, OPPG, OPS, OPTA1, PCLD4, VBCH2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Wnt-protein binding
- Wnt receptor
- Low-density lipoprotein receptor repeat class B
- protein binding
- NHL repeat unit of beta-propeller proteins
- Wnt binding domain
- cytoplasmic domain
- transmembrane domain
- LDLa
- intracellular domain
- cytosolic tail domain
- Low-density lipoprotein-receptor YWTD domain
- transmembrane receptor
- Coagulation Factor Xa inhibitory site
- coreceptor
Pathways
Biological processes and signaling networks where the Lrp5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Molecular Mechanisms of Cancer
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- VDR/RXR Activation
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colon epithelial cancer
- colorectal cancer
- epithelial cancer
- gastrointestinal neoplasia
- endometriosis
- osteoarthritis
- osteoporosis
- osteoporosis-pseudoglioma syndrome
- aortic valve calcification
phenotypes
- abnormal b-wave shape
- abnormal blood-retinal barrier function
- abnormal bone mineralization
- abnormal bone ossification
- abnormal bone structure
- abnormal bone trabecula morphology
- abnormal calcium ion homeostasis
- abnormal cone electrophysiology
- abnormal eye development
- abnormal femur morphology
- abnormal limb morphology
- abnormal liver physiology
- abnormal long bone diaphysis morphology
- abnormal lumbar vertebrae morphology
- abnormal osteoblast physiology
- abnormal phalanx morphology
- abnormal retina morphology
- abnormal retinal blood vessel morphology
- abnormal retinal layer morphology
- abnormal retinal nerve fiber layer morphology
- abnormal retinal neuronal layer morphology
- abnormal retinal outer nuclear layer morphology
- abnormal retinal outer plexiform layer morphology
- abnormal retinal pigment epithelium morphology
- abnormal retinal vasculature morphology
- abnormal trabecular bone morphology
- abnormal vascular plexus formation
- abnormal vision
- decreased a wave amplitude
- decreased apoptosis
- decreased areal bone mineral density
- decreased b wave amplitude
- decreased body weight
- decreased bone mass
- decreased bone mineral content
- decreased bone mineral density
- decreased bone mineralization
- decreased bone ossification
- decreased bone resorption
- decreased bone stiffness
- decreased bone strength
- decreased bone volume
- decreased circulating insulin level
- decreased compact bone mass
- decreased diameter of femur
- decreased diameter of tibia
- decreased insulin secretion
- decreased osteoblast cell number
- decreased osteoclast cell number
- decreased serotonin level
- decreased total retina thickness
- decreased trabecular bone mass
- delayed bone ossification
- disorganized retinal inner nuclear layer
- disorganized retinal outer nuclear layer
- disorganized retinal outer plexiform layer
- gliosis
- hypoactivity
- impaired glucose tolerance
- increased bone mass
- increased cholesterol level
- increased circulating VLDL cholesterol level
- increased serotonin level
- increased thigmotaxis
- increased vascular permeability
- insulin resistance
- no abnormal phenotype detected
- osteoporosis
- persistence of hyaloid vascular system
- postnatal lethality incomplete penetrance
- retinal degeneration
- retinal ganglion cell degeneration
- retinal photoreceptor degeneration
- thin parietal bone
- thin retinal inner plexiform layer
- thin retinal outer nuclear layer
- thin retinal outer plexiform layer
- vasculature congestion
role in cell
- downregulation in
- accumulation in
- phosphorylation in
- apoptosis
- motility
- expression in
- activation in
- translocation
- differentiation
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion involved in cellular response to glucose stimulus
- retina morphogenesis in camera-type eye
- positive regulation of cell proliferation
- anterior/posterior pattern specification
- bone morphogenesis
- nervous system development
- cholesterol metabolic process
- positive regulation of fat cell differentiation
- positive regulation of mitosis
- positive regulation of osteoblast differentiation
- branching involved in mammary gland duct morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- amino acid transport
- glucose catabolic process
- cholesterol homeostasis
- cell-cell signaling involved in mammary gland development
- bone marrow development
- embryonic digit morphogenesis
- negative regulation of osteoblast differentiation
- positive regulation of transcription, DNA-dependent
- gastrulation with mouth forming second
- somatic stem cell maintenance
- canonical Wnt receptor signaling pathway
- anatomical structure regression
- positive regulation of osteoblast proliferation
- bone remodeling
- mesodermal cell migration
- establishment of blood-brain barrier
- positive regulation of mesenchymal cell proliferation
- regulation of apoptotic process
- osteoblast development
- endocytosis
- regulation of blood pressure
- response to peptide hormone stimulus
- retinal blood vessel morphogenesis
- adipose tissue development
- cell migration involved in gastrulation
- extracellular matrix-cell signaling
- osteoblast proliferation
- gene expression
- negative regulation of protein serine/threonine kinase activity
Cellular Component
Where in the cell the gene product is active
- receptor complex
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- Wnt-activated receptor activity
- protein binding
- Wnt-protein binding
- toxin transporter activity