Axin1 Gene Summary [Mouse]
Enables several functions, including SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in negative regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; and positive regulation of protein kinase activity. Acts upstream of or within several processes, including chordate embryonic development; regulation of Wnt signaling pathway; and regulation of macromolecule metabolic process. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and microtubule cytoskeleton. Part of Wnt signalosome and beta-catenin destruction complex. Is expressed in several structures, including eye; forebrain; genitourinary system; hemolymphoid system gland; and jaw. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and urinary bladder cancer. Orthologous to human AXIN1 (axin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Axin1 |
| Official Name | axin 1 [Source:MGI Symbol;Acc:MGI:1096327] |
| Ensembl ID | ENSMUSG00000024182 |
| Bio databases IDs | |
| Aliases | axin 1 |
| Synonyms | AXIN, AXIN form I, CMDOH, Fu, fused, Kb, Ki, kinky, knobbly, PPP1R49 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Axin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- Sumoylation motif
- ATP-binding domain
- Axin beta-catenin binding motif
- protein binding activity, bridging
- coiled-coil domain
- APC binding domain
- identical protein binding
- beta-catenin binding domain
- DIX domain
- ubiquitin protein ligase binding
- protein kinase binding
- beta-catenin binding
- enzyme binding
- Regulator of G protein signaling (RGS) domain superfamily
- protein domain specific binding
- protein binding
- receptor binding
- Tankyrase binding N-terminal segment of axin
- p53 binding
- MEKK1 binding domain
- Regulator of G protein signaling domain
- protein kinase activator
- GSK-3beta binding domain
- protein homodimerization
- PP2A-binding domain
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Axin1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Basal Cell Carcinoma Signaling
- Colorectal Cancer Metastasis Signaling
- Endometrial Cancer Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Ovarian Cancer Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Sertoli Cell-Sertoli Cell Junction Signaling
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- plasma cell myeloma
- non-insulin-dependent diabetes mellitus
- cardiovascular disorder
- non-small cell lung cancer
- non-small cell lung carcinoma
- osteoporosis
- abdominal cancer
role in cell
- expression in
- phosphorylation in
- apoptosis
- differentiation
- inhibition in
- activation in
- proliferation
- formation
- formation in
- expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cell periphery
- perinuclear region
- cell cortex
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytosol
- lateral plasma membrane
- nucleoli
- nuclear envelope
- synapse
- cytoplasmic vesicles
- lateral cell-cell contacts
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Axin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- head development
- dorsal/ventral axis specification
- sensory perception of sound
- axial mesoderm formation
- nucleocytoplasmic transport
- in utero embryonic development
- apoptotic process
- positive regulation of protein ubiquitination
- canonical Wnt receptor signaling pathway
- activation of protein kinase activity
- negative regulation of protein metabolic process
- positive regulation of peptidyl-serine phosphorylation
- macromolecular complex assembly
- negative regulation of transcription elongation from RNA polymerase II promoter
- protein polyubiquitination
- negative regulation of fat cell differentiation
- positive regulation of protein catabolic process
- cell development
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of gene expression
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of protein kinase activity
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- positive regulation of peptidyl-threonine phosphorylation
- cytoplasmic microtubule organization
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- microtubule cytoskeleton
- nucleolus
- plasma membrane
- beta-catenin destruction complex
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cell cortex
- cytosol
- cytoplasmic vesicle
- cell periphery
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein homodimerization activity
- signaling adaptor activity
- beta-catenin binding
- p53 binding
- ubiquitin protein ligase binding
- protein binding
- SMAD binding
- armadillo repeat domain binding
- R-SMAD binding
- I-SMAD binding
- binding, bridging
- enzyme binding