Igsf5 Gene Summary [Mouse]

Enables PDZ domain binding activity. Acts upstream of or within cell-cell adhesion. Located in bicellular tight junction and cell surface. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and respiratory system. Orthologous to human IGSF5 (immunoglobulin superfamily member 5). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Igsf5
Official Name
immunoglobulin superfamily, member 5 [Source:MGI Symbol;Acc:MGI:1919308]
Ensembl ID
ENSMUSG00000000159
Bio databases IDs NCBI: 72058 Ensembl: ENSMUSG00000000159
Aliases immunoglobulin superfamily, member 5
Synonyms 2010003D20Rik, GSF5, immunoglobulin superfamily member 5, immunoglobulin superfamily, member 5, JAM4, JCAM, LOC102724786
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igsf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • immunoglobulin domain
  • Immunoglobulin like
  • Immunoglobulin I-set domain
  • protein binding
  • PDZ-domain binding

Pathways

Biological processes and signaling networks where the Igsf5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hypertension
  • breast cancer

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cell surface
  • tight junctions

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Igsf5 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • tight junction
  • apical plasma membrane
  • cell surface

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.