Rbp4 Gene Summary [Mouse]

Enables molecular carrier activity and retinol binding activity. Involved in several processes, including embryonic morphogenesis; heart development; and reproductive structure development. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; retinoid metabolic process; and terpenoid transport. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hindlimb. Human ortholog(s) of this gene implicated in coronary artery disease and type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Rbp4
Official Name
retinol binding protein 4, plasma [Source:MGI Symbol;Acc:MGI:97879]
Ensembl ID
ENSMUSG00000024990
Bio databases IDs NCBI: 19662 Ensembl: ENSMUSG00000024990
Aliases retinol binding protein 4, plasma
Synonyms APP-BP, Crbp IV, MCOPCB10, PLASMA RETINOL-binding, PRBP, RBP, RBPA, Rbp w14367, RDCCAS, retinol binding protein 4, retinol binding protein 4, plasma
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • binding protein
  • lipocalin/cytosolic fatty acid-binding protein family
  • retinol binding
  • protein binding
  • Lipocalin / cytosolic fatty-acid binding protein family

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • osteoarthritis
  • colorectal cancer
  • hereditary disorder
  • epithelial cancer
  • liver cancer
  • hypoplasia
  • follicular adenoma
  • adenoma formation
  • Ullrich congenital muscular dystrophy
  • non-insulin-dependent diabetes mellitus
regulated by
regulates
role in cell
  • production in
  • expression in
  • apoptosis
  • proliferation
  • phosphorylation in
  • surface area
  • activation
  • abnormal morphology
  • signaling in
  • lipolysis in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • cytosol
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbp4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of cardiac muscle cell proliferation
  • gluconeogenesis
  • female genitalia morphogenesis
  • vagina development
  • urinary bladder development
  • uterus development
  • retinol metabolic process
  • visual perception
  • embryonic retina morphogenesis in camera-type eye
  • embryonic skeletal system development
  • cardiac muscle tissue development
  • heart trabecula formation
  • embryonic organ morphogenesis
  • heart development
  • response to retinoic acid
  • eye development
  • glucose homeostasis
  • positive regulation of immunoglobulin production
  • retinol transport
  • maintenance of gastrointestinal epithelium
  • positive regulation of insulin secretion
  • lung development

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • extracellular vesicular exosome
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • retinol transporter activity
  • retinal binding
  • retinol binding

Gene-Specific Assays for Results You Can Trust

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