Epn2 Gene Summary [Mouse]
Predicted to enable clathrin binding activity and phospholipid binding activity. Acts upstream of or within Notch signaling pathway; embryonic organ development; and in utero embryonic development. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of clathrin coat of endocytic vesicle. Predicted to be active in endosome and plasma membrane. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human EPN2 (epsin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epn2 |
| Official Name | epsin 2 [Source:MGI Symbol;Acc:MGI:1333766] |
| Ensembl ID | ENSMUSG00000001036 |
| Bio databases IDs | |
| Aliases | epsin 2 |
| Synonyms | 9530051D10Rik, AA536924, EHB21, epsin 2, Ibp2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- clathrin binding domain
- DPW domain
- NPF motif
- VHS, ENTH and ANTH domain superfamily
- Eps15 homology binding domain
- protein binding
- ENTH domain
Pathways
Biological processes and signaling networks where the Epn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by Dengue virus 2
- schizophrenia
- weight gain
- white matter hyperintensities
role in cell
- endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- cytosol
- vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Epn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- endocytosis
- positive regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- endosome
- intracellular membrane-bounded organelle
- cytosol
- clathrin vesicle coat
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- clathrin binding
- phospholipid binding