Cbfb Gene Summary [Mouse]
Contributes to sequence-specific DNA binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of CD8-positive, alpha-beta T cell differentiation. Acts upstream of or within several processes, including hemopoiesis; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbfb |
| Official Name | core binding factor beta [Source:MGI Symbol;Acc:MGI:99851] |
| Ensembl ID | ENSMUSG00000031885 |
| Bio databases IDs | |
| Aliases | core binding factor beta |
| Synonyms | AMLCR2, Cbf beta, Cbf β, CLCD2, core binding factor beta, core-binding factor, beta subunit, core-binding factor subunit beta, core-binding factor subunit β, core binding factor β, PEA2, PEA2-beta, PEA2-β, Pebp2, PEBP2B, Pebp2 beta, Pebp2 β, Pebpb2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cbfb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Core binding factor beta subunit
- basic helix-loop-helix-leucine zipper domain
- heterodimerization domain
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- acute myeloid leukemia
- edema
- intraventricular hemorrhage
- autoimmune disease
- cleidocranial dysplasia type 2
- aortic valve calcification
- T acute lymphoblastic leukemia
- metastasis
- bleeding
role in cell
- expression in
- proliferation
- apoptosis
- survival
- migration
- quantity
- maturation
- differentiation
- accumulation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytoskeleton
- Cytoplasm
- Golgi Apparatus
- nucleoplasm
- Z line
- actin stress fibers
- membrane processes
- cytoskeletal fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cbfb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- transcription from RNA polymerase II promoter
- positive regulation of CD8-positive, alpha-beta T cell differentiation
- cell maturation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- definitive hemopoiesis
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of CD4-positive, alpha-beta T cell differentiation
- osteoblast differentiation
- myeloid cell differentiation
- lymphocyte differentiation
Cellular Component
Where in the cell the gene product is active
- core-binding factor complex
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- sequence-specific DNA binding