Srr Gene Summary [Mouse]
Enables several functions, including amino-acid racemase activity; anion binding activity; and identical protein binding activity. Acts upstream of or within D-serine biosynthetic process and L-serine metabolic process. Predicted to be located in apical part of cell and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in facial bone primordium and nervous system. Used to study schizophrenia. Orthologous to human SRR (serine racemase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Srr |
| Official Name | serine racemase [Source:MGI Symbol;Acc:MGI:1351636] |
| Ensembl ID | ENSMUSG00000001323 |
| Bio databases IDs | |
| Aliases | serine racemase |
| Synonyms | ILV1, ISO1, M100034, Rgsc34, Serine racemase, Srs |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trp-synth-beta_II
- ATP binding
- calcium ion binding
- enzyme
- protein binding
- magnesium ion binding
- identical protein binding
- threonine racemase
- PDZ-domain binding
- serine racemase
- pyridoxal phosphate binding
- Pyridoxal-phosphate dependent enzyme
- glycine binding
- L-serine ammonia-lyase
- protein homodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- schizophrenia
- non-insulin-dependent diabetes mellitus
- pervasive developmental disorder
- hyperactive behavior
- osteoarthritis
role in cell
- cell death
- generation in
- long-term potentiation
- synaptic plasticity
- long-term potentiation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- membrane fraction
- apical compartment
- perinuclear region
- Golgi Apparatus
- cytosol
- neurites
- perikaryon
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyruvate biosynthetic process
- D-serine metabolic process
- L-serine metabolic process
- response to lipopolysaccharide
- D-serine biosynthetic process
- serine family amino acid metabolic process
- response to xenobiotic stimulus
- response to organic cyclic compound
Cellular Component
Where in the cell the gene product is active
- apical part of cell
- cytoplasm
- cytosol
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- identical protein binding
- protein homodimerization activity
- D-serine ammonia-lyase activity
- magnesium ion binding
- ATP binding
- L-serine ammonia-lyase activity
- protein binding
- calcium ion binding
- PDZ domain binding
- glycine binding
- threonine racemase activity
- serine racemase activity