Nrip2 Gene Summary [Mouse]
Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in brain and heart. Orthologous to human NRIP2 (nuclear receptor interacting protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrip2 |
| Official Name | nuclear receptor interacting protein 2 [Source:MGI Symbol;Acc:MGI:1891884] |
| Ensembl ID | ENSMUSG00000001520 |
| Bio databases IDs | |
| Aliases | nuclear receptor interacting protein 2 |
| Synonyms | AW491344, LOC100364151, LOC683559, NIX1, nuclear receptor interacting protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LXXLL motif
- protein binding
- Cellular and retroviral pepsin-like aspartate proteases
- gag-polyprotein putative aspartyl protease
Pathways
Biological processes and signaling networks where the Nrip2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- aspartic-type endopeptidase activity
- protein binding