Sf3a2 Gene Summary [Mouse]
Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in U2-type prespliceosome assembly and positive regulation of neuron projection development. Predicted to act upstream of or within RNA splicing, via transesterification reactions. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP and spliceosomal complex. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human SF3A2 (splicing factor 3a subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sf3a2 |
| Official Name | splicing factor 3a, subunit 2 [Source:MGI Symbol;Acc:MGI:104912] |
| Ensembl ID | ENSMUSG00000020211 |
| Bio databases IDs | |
| Aliases | splicing factor 3a, subunit 2 |
| Synonyms | AW047242, PRP11, PRPF11, SAP62, SF3a66, SFA66, splicing factor 3A subunit 2, splicing factor 3a, subunit 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sf3a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cactus-binding C-terminus of cactin protein
- C-terminal heptad repeat domain
- U1 zinc finger
- protein binding
- zinc finger domain
- Zinc-finger of C2H2 type
Pathways
Biological processes and signaling networks where the Sf3a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- overnutrition
- Hutchinson-Gilford progeria syndrome
- morbid obesity
regulated by
- lipopolysaccharide
- topotecan
- Ebna2
- SFPQ
- NOMO
- Major late
- Lmp2a
regulates
role in cell
- growth
- splicing by
- alternative splicing in
- cell death
- development
- innate immune response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sf3a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of neuron projection development
- mRNA processing
- nuclear mRNA 3'-splice site recognition
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- nuclear speck
- spliceosomal complex
- U2-type spliceosomal complex
- U2-type prespliceosome
- U2-type precatalytic spliceosome
- U2 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA binding