Tnk1 Gene Summary [Mouse]
Enables ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of cell growth; and protein autophosphorylation. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; pituitary gland; respiratory system; and thymus. Orthologous to human TNK1 (tyrosine kinase non receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnk1 |
| Official Name | tyrosine kinase, non-receptor, 1 [Source:MGI Symbol;Acc:MGI:1930958] |
| Ensembl ID | ENSMUSG00000001583 |
| Bio databases IDs | |
| Aliases | tyrosine kinase, non-receptor, 1 |
| Synonyms | KOS1, Tnk1a, Tnk1b, tyrosine kinase non receptor 1, tyrosine kinase, non-receptor, 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- ATP binding
- non-membrane spanning protein tyrosine kinase
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Tnk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- non-small cell lung cancer
- lymphomagenesis
- cancer
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- gastrointestinal neoplasia
role in cell
- expression in
- cell viability
- phosphorylation in
- production in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein autophosphorylation
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity