Akr1b3 Gene Summary [Mouse]
Enables L-glucuronate reductase activity and aldose reductase (NADPH) activity. Involved in L-ascorbic acid biosynthetic process and fructose biosynthetic process. Acts upstream of or within several processes, including metanephric collecting duct development; regulation of urine volume; and renal water homeostasis. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Akr1b3 |
| Official Name | aldo-keto reductase family 1, member B3 (aldose reductase) [Source:MGI Symbol;Acc:MGI:1353494] |
| Ensembl ID | ENSMUSG00000001642 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 1, member B3 (aldose reductase) |
| Synonyms | ADR, Ahr-1, Akr1b3, Akr1b4, aldo-keto reductase family 1 member B, aldo-keto reductase family 1 member B1, Aldolase Reductase, Aldor1, Aldose Reductase, ALDR1, ALDRED, Alr, ALR2, ALR-P-I, Androgen-induced aldose reductase, AR, RATALDRED |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akr1b3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- electron carrier
- L-glucuronate reductase
- Aldo-keto reductase (AKR) superfamily
- retinal dehydrogenase
- aldehyde or oxo group oxidoreductase
- Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
- CH-OH group:NAD or NADP oxidoreductase
- Aldo/keto reductase family
- enzyme
- protein binding
- aldehyde reductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- neoplasia
- lung neoplasm
- breast cancer
- diabetes mellitus
- hypercalciuria
- prostatic neoplasm
- prostatic neoplasia
- polydipsia
- stomach neoplasm
regulated by
- 4-hydroxynonenal
- IL1B
- 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron (III)
- tetrachlorodibenzodioxin
- oleanolic acid
- sorbinil
- epalrestat
- Sertoli cells
- phenylglyoxal
- N-nitro-L-arginine methyl ester
role in cell
- expression in
- phosphorylation in
- apoptosis
- proliferation
- aggregation
- adhesion
- growth
- senescence
- response by
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- lysosome
- Mitochondria
- cytosol
- nucleoplasm
- paranodal junctions
- Schmidt-Lanterman incisures
- glial cell projections
- cellular protrusions
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akr1b3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- renal water homeostasis
- epithelial cell maturation
- retinol metabolic process
- daunorubicin metabolic process
- prostaglandin metabolic process
- doxorubicin metabolic process
- C21-steroid hormone biosynthetic process
- regulation of urine volume
- carbohydrate metabolic process
- fructose biosynthetic process
- retinoid metabolic process
- cellular hyperosmotic salinity response
- negative regulation of apoptotic process
- metanephric collecting duct development
- L-ascorbic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- L-glucuronate reductase activity
- protein binding
- NADP-retinol dehydrogenase activity
- prostaglandin H2 endoperoxidase reductase activity
- electron carrier activity
- retinal dehydrogenase activity
- alditol:NADP+ 1-oxidoreductase activity
- allyl-alcohol dehydrogenase activity
- glyceraldehyde oxidoreductase activity
- glycerol dehydrogenase (NADP+) activity