Ndst2 Gene Summary [Mouse]
Enables N-acetylglucosamine deacetylase activity; heparan sulfate N-deacetylase activity; and heparan sulfate N-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Acts upstream of or within mast cell mediated immunity and regulation of angiotensin levels in blood. Located in Golgi apparatus. Is expressed in several structures, including brain; exocrine system; genitourinary system; liver; and spleen. Orthologous to human NDST2 (N-deacetylase and N-sulfotransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndst2 |
| Official Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 [Source:MGI Symbol;Acc:MGI:97040] |
| Ensembl ID | ENSMUSG00000039308 |
| Bio databases IDs | |
| Aliases | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 |
| Synonyms | HSST2, MNDNS, NCST2, N-deacetylase and N-sulfotransferase 2, N-deacetylase and N-sulphotransferase 2, N-deacetylase/n-sulfotransferase-2, N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2, N-deacetylase/N-sulphotransferase (heparan glucosaminyl) 2, N-Deacetylase/N-sulphotransferase (mastocytoma), NEWGENE 1304700, N-HSST 2, NST2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndst2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- sulfotransferase
- [heparan sulfate]-glucosamine N-sulfotransferase
- N-acetylglucosamine deacetylase
- Sulfotransferase domain
- enzyme
- deacetylase
- Sulfotransferase family
- heparan sulfate-N-deacetylase
Pathways
Biological processes and signaling networks where the Ndst2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- arthritis
- myocardial infarction
role in cell
- quantity
- degranulation
- morphology
- number
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndst2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, enzymatic modification
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
- mast cell mediated immunity
- heparin biosynthetic process
- regulation of angiotensin levels in blood
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- [heparan sulfate]-glucosamine N-sulfotransferase activity
- N-acetylglucosamine deacetylase activity
- deacetylase activity