Prkar2b Gene Summary [Mouse]
Enables cAMP-dependent protein kinase regulator activity and protein kinase binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within fatty acid metabolic process and learning. Located in ciliary base; cytoplasm; and dendrite. Part of cAMP-dependent protein kinase complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; liver; primary palate; retina; and testis. Orthologous to human PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkar2b |
| Official Name | protein kinase, cAMP dependent regulatory, type II beta [Source:MGI Symbol;Acc:MGI:97760] |
| Ensembl ID | ENSMUSG00000002997 |
| Bio databases IDs | |
| Aliases | protein kinase, cAMP dependent regulatory, type II beta |
| Synonyms | Pkarb2, Pka riib, PKARIIbeta, Pka rII β, PRKAR2, protein kinase, cAMP dependent regulatory, type II beta, protein kinase, cAMP dependent regulatory, type II β, protein kinase cAMP-dependent type II regulatory subunit beta, protein kinase cAMP-dependent type II regulatory subunit β, R2 β, RATDNA, RII-BETA, RII(beta), RII-β, RII(β) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkar2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cAMP binding domain
- ubiquitin protein ligase binding
- AKAP binding domain
- protein kinase
- dimerization domain
- protein kinase A binding
- protein kinase binding
- protein domain specific binding
- DD_R_PKA_DPY30-like
- protein binding
- cAMP-dependent protein kinase regulator
- Cyclic nucleotide-monophosphate binding domain
- kinase
- Cyclic nucleotide-binding domain
- cAMP-dependent protein kinase inhibitor activity
- 3',5'-cAMP binding
- catalytic subunit-binding domain
- CAP_ED
Pathways
Biological processes and signaling networks where the Prkar2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- BMP signaling pathway
- Calcium Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Endocannabinoid Developing Neuron Pathway
- eNOS Signaling
- Ephrin A Signaling
- Gαs Signaling
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Myc Mediated Apoptosis Signaling
- Netrin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- PXR/RXR Activation
- Relaxin Signaling
- Renin-Angiotensin Signaling
- Sonic Hedgehog Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- obesity
- schizophrenia
- catalepsy
- Alzheimer disease
- headache
- hyperphagia
- weight gain
- bladder carcinoma
- polycystic ovary syndrome
role in cell
- expression in
- apoptosis
- activation in
- growth
- morphology
- phosphorylation in
- differentiation
- incorporation in
- signal transduction in
- quiescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- microtubule aster fraction
- soluble fraction
- membrane fraction
- glutaminergic synapse
- Golgi-centrosome region
- Golgi region
- perinuclear region
- postsynaptic region
- Nucleus
- Plasma Membrane
- centrosome
- Golgi Apparatus
- cytosol
- dendritic spines
- neurites
- synapse
- cytoplasmic vesicles
- perikaryon
- dendrites
- dendritic shafts
- mossy fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkar2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cAMP-dependent protein kinase activity
- regulation of protein phosphorylation
- regulation of synaptic transmission
- learning
- intracellular signal transduction
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- dendritic shaft
- dendritic spine
- cytosol
- neuronal cell body
- cAMP-dependent protein kinase complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- ubiquitin protein ligase binding
- protein binding
- protein kinase A catalytic subunit binding
- cAMP binding
- cAMP-dependent protein kinase regulator activity
- cAMP-dependent protein kinase inhibitor activity