Rin1 Gene Summary [Mouse]
Enables small GTPase binding activity. Acts upstream of or within associative learning; memory; and negative regulation of synaptic plasticity. Located in dendrite and neuronal cell body. Is expressed in brain; gonad; and thyroid gland. Orthologous to human RIN1 (Ras and Rab interactor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rin1 |
| Official Name | Ras and Rab interactor 1 [Source:MGI Symbol;Acc:MGI:2385695] |
| Ensembl ID | ENSMUSG00000024883 |
| Bio databases IDs | |
| Aliases | Ras and Rab interactor 1 |
| Synonyms | LOC108348044, Ras and Rab interactor 1, RAS INHIBITOR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubl1_cv_Nsp3_N-like
- Rab5 binding domain
- VPS9p domain
- Ras-binding domain
- ABL binding domain
- Vacuolar sorting protein 9 (VPS9) domain
- enzyme binding
- Src homology 2 (SH2) domain
- protein binding
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
role in cell
- phosphorylation in
- expression in
- formation
- proliferation
- migration
- adhesion
- motility
- signaling in
- transformation
- malignancy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- cytosol
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- endocytosis
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- cytoskeleton
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- GTPase activator activity
- small GTPase binding