SRPK3 Gene Summary [Human]
This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Details
| Type | Protein Coding |
| Official Symbol | SRPK3 |
| Official Name | SRSF protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:11402] |
| Ensembl ID | ENSG00000184343 |
| Bio databases IDs | |
| Aliases | SRSF protein kinase 3 |
| Synonyms | MSSK-1, serine/arginine-rich protein specific kinase 3, SRSF protein kinase 3, STK23, XLID114 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRPK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked mental retardation
- centronuclear myopathy
- congenital myopathy
- productive infection by HIV-1
role in cell
- expression in
- growth
- proliferation
- differentiation
- degeneration
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRPK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mRNA processing
- skeletal muscle tissue development
- cell differentiation
- muscle tissue development
- peptidyl-serine phosphorylation
- intracellular signal transduction
- spliceosomal complex assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity