Ddx56 Gene Summary [Mouse]
Predicted to enable RNA stem-loop binding activity and protein sequestering activity. Predicted to be involved in defense response to virus; negative regulation of type I interferon production; and positive regulation of neuron projection development. Predicted to act upstream of with a negative effect on modulation by host of viral RNA genome replication. Located in nucleolus. Orthologous to human DDX56 (DEAD-box helicase 56). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx56 |
| Official Name | DEAD box helicase 56 [Source:MGI Symbol;Acc:MGI:1277172] |
| Ensembl ID | ENSMUSG00000004393 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 56 |
| Synonyms | 2600001H07Rik, D11Ertd619e, DDX21, DDX26, DEAD-box helicase 56, DEAD-box protein 56, LOC100911468, LOC103693777, NOH61, RH-II/Gu |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx56 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- RNA helicase
- P-loop containing Nucleoside Triphosphate Hydrolases
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- breast carcinoma
- renal clear cell adenocarcinoma
- renal clear cell cancer
- breast cancer
- head and neck squamous cell carcinoma
role in cell
- growth
- survival
- replication in
- development
- pluripotency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- granular components
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx56 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of type I interferon production
- defense response to virus
- positive regulation of neuron projection development
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- RNA helicase activity
- RNA stem-loop binding