Ddb2 Gene Summary [Mouse]
Predicted to contribute to damaged DNA binding activity and ubiquitin-protein transferase activity. Involved in DNA damage response and cellular response to UV. Acts upstream of or within pyrimidine dimer repair. Part of Cul4A-RING E3 ubiquitin ligase complex. Used to study xeroderma pigmentosum group E. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group E. Orthologous to human DDB2 (damage specific DNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ddb2 |
| Official Name | damage specific DNA binding protein 2 [Source:MGI Symbol;Acc:MGI:1355314] |
| Ensembl ID | ENSMUSG00000002109 |
| Bio databases IDs | |
| Aliases | damage specific DNA binding protein 2 |
| Synonyms | 2610043A19Rik, damage specific DNA binding protein 2, DDBB, UV-DDB2, XPE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- binding protein
- WD40 repeats
- damaged DNA binding
- ubiquitin-protein transferase activity
- WD domain, G-beta repeat
- WD40
- protein binding
- UV-damaged DNA-binding factor 1 binding domain
- DNA binding
Pathways
Biological processes and signaling networks where the Ddb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- squamous-cell carcinoma
- squamous cell cancer
- T-cell non-Hodgkin disease
- androgenic alopecia
- cardiomyopathy
- xeroderma pigmentosum complementation group E DDB-negative form
role in cell
- expression in
- apoptosis
- cell death
- degradation in
- colony formation
- activation in
- proliferation
- accumulation in
- motility
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cell junction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- pyrimidine dimer repair
- UV-damage excision repair
- protein polyubiquitination
- cellular response to UV
- nucleotide-excision repair
- response to UV
- response to DNA damage stimulus
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- Cul4A-RING ubiquitin ligase complex
- cell junction
- Cul4B-RING ubiquitin ligase complex
- macromolecular complex
- chromatin
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ubiquitin-protein ligase activity
- protein binding
- damaged DNA binding