DYRK1B Gene Summary [Human]
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Details
| Type | Protein Coding |
| Official Symbol | DYRK1B |
| Official Name | dual specificity tyrosine phosphorylation regulated kinase 1B [Source:HGNC Symbol;Acc:HGNC:3092] |
| Ensembl ID | ENSG00000105204 |
| Bio databases IDs | |
| Aliases | dual specificity tyrosine phosphorylation regulated kinase 1B, minibrain-related kinase |
| Synonyms | AOMS3, dual specificity tyrosine phosphorylation regulated kinase 1B, MIRK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DYRK1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- subdomain of kinase domain
- protein threonine/tyrosine kinase
- transcription co-activator
- ATP-binding domain
- nuclear localization sequence
- leucine zipper domain
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- PEST domain
- kinase domain
- Protein Kinases, catalytic domain
- active site
Pathways
Biological processes and signaling networks where the DYRK1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- nonalcoholic steatohepatitis
- hypertriglyceridemia
- heart failure
- hepatic steatosis
- hypercholesterolemia
- abdominal obesity-metabolic syndrome 3
- hepatic fibrosis
- fibrosis
role in cell
- expression in
- accumulation in
- survival
- migration
- activation in
- cell viability
- phosphorylation in
- accumulation
- fusion
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DYRK1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of transcription, DNA-dependent
- myoblast fusion
- peptidyl-serine phosphorylation
- protein phosphorylation
- peptidyl-threonine phosphorylation
- adipose tissue development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein serine/threonine/tyrosine kinase activity
- protein binding
- transcription coactivator activity
- protein kinase activity
- protein serine/threonine kinase activity