Rab1b Gene Summary [Mouse]
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including autophagosome assembly; positive regulation of glycoprotein metabolic process; and regulation of autophagosome assembly. Located in endoplasmic reticulum-Golgi intermediate compartment. Is expressed in diaphragm. Orthologous to several human genes including RAB1B (RAB1B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab1b |
| Official Name | RAB1B, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1923558] |
| Ensembl ID | ENSMUSG00000024870 |
| Bio databases IDs | |
| Aliases | RAB1B, member RAS oncogene family |
| Synonyms | 1110011F09RIK, Rab1bl, RAB1B, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic juvenile idiopathic arthritis
- insomnia
- infection by HIV-1
- productive infection by HIV-1
role in cell
- expression in
- binding in
- assembly
- formation
- fragmentation
- size
- organization
- transactivation in
- induction in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell center
- perinuclear Golgi regions
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- lipid droplets
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum exit sites
- Golgi membrane
- synapse
- transport vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- ER to Golgi vesicle-mediated transport
- Golgi organization
- regulation of autophagic vacuole assembly
- virion assembly
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- pre-autophagosomal structure membrane
- cytosol
- endomembrane system
- Golgi membrane
- Golgi apparatus
- transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity