Nosip Gene Summary [Mouse]
Predicted to enable molecular sequestering activity. Predicted to be involved in negative regulation of nitric-oxide synthase activity and regulation of nitric oxide biosynthetic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain and cerebral cortex. Used to study holoprosencephaly. Orthologous to human NOSIP (nitric oxide synthase interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nosip |
| Official Name | nitric oxide synthase interacting protein [Source:MGI Symbol;Acc:MGI:1913644] |
| Ensembl ID | ENSMUSG00000003421 |
| Bio databases IDs | |
| Aliases | nitric oxide synthase interacting protein |
| Synonyms | 2310061K06Rik, CGI-25, nitric oxide synthase interacting protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nosip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Zinc-finger of nitric oxide synthase-interacting protein
- protein binding
Pathways
Biological processes and signaling networks where the Nosip gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- prostatic carcinoma
- schizophrenia
role in cell
- proliferation
- survival
- processing in
- JG-231 sensitivity
- pladienolide B sensitivity
- thenoyltrifluoroacetone sensitivity
- ribociclib resistance
- palbociclib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- Golgi membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nosip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of catalytic activity
- negative regulation of nitric-oxide synthase activity
- regulation of nitric oxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Golgi membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding