Cyp4f18 Gene Summary [Mouse]
Enables long-chain fatty acid omega-1 hydroxylase activity. Involved in leukotriene B4 metabolic process. Predicted to be located in apical plasma membrane; cytoplasm; and intracellular membrane-bounded organelle. Orthologous to human CYP4F3 (cytochrome P450 family 4 subfamily F member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp4f18 |
| Official Name | cytochrome P450, family 4, subfamily f, polypeptide 18 [Source:MGI Symbol;Acc:MGI:1919304] |
| Ensembl ID | ENSMUSG00000003484 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 4, subfamily f, polypeptide 18 |
| Synonyms | 1810054N16Rik, CPF2, Cyp4f18, Cyp4f3, Cypf18, CYPIVF3, cytochrome P450 family 4 subfamily F member 2, cytochrome P450, family 4, subfamily f, polypeptide 18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp4f18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- reduced flavin or flavoprotein:oxygen oxidoreductase
- leukotriene-B4 20-monooxygenase
- monooxygenase
- CH-OH group oxidoreductase
- enzyme
- protein binding
- arachidonic acid epoxygenase
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
- alkane 1-monooxygenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- liver cancer
- epithelial cancer
- lymphomagenesis
- COVID-19
- streptozotocin induced type1 diabetes
- dermatological disorder
- hepatitis B virus-related hepatocellular carcinoma
- lymphoma
- psoriasis like inflammation
role in cell
- proliferation
- expression in
- production in
- number
- tubulation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endoplasmic reticulum membrane
- microsome
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyp4f18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene B4 catabolic process
- renal water homeostasis
- leukotriene metabolic process
- sodium ion homeostasis
- pressure natriuresis
- icosanoid metabolic process
- phylloquinone catabolic process
- blood coagulation
- vitamin K catabolic process
- very long-chain fatty acid metabolic process
- regulation of blood pressure
- long-chain fatty acid metabolic process
- omega-hydroxylase P450 pathway
- epoxygenase P450 pathway
- vitamin E metabolic process
- menaquinone catabolic process
- xenobiotic metabolic process
- negative regulation of icosanoid secretion
- positive regulation of icosanoid secretion
- arachidonic acid metabolic process
- fatty acid omega-oxidation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- intracellular membrane-bounded organelle
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- arachidonic acid epoxygenase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
- leukotriene-B4 20-monooxygenase activity
- monooxygenase activity
- heme binding
- protein binding
- 20-hydroxy-leukotriene B4 omega oxidase activity
- iron ion binding
- alpha-tocopherol omega-hydroxylase activity
- aromatase activity
- 20-aldehyde-leukotriene B4 20-monooxygenase activity
- arachidonic acid omega-hydroxylase activity
- alkane 1-monooxygenase activity