Dusp3 Gene Summary [Mouse]
Enables protein tyrosine/serine/threonine phosphatase activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; and regulation of focal adhesion assembly. Acts upstream of or within protein dephosphorylation. Is active in axonemal microtubule doublet inner sheath and sperm flagellum. Is expressed in central nervous system; dorsal root ganglion; retina; and urinary system. Orthologous to human DUSP3 (dual specificity phosphatase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp3 |
| Official Name | dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) [Source:MGI Symbol;Acc:MGI:1919599] |
| Ensembl ID | ENSMUSG00000003518 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) |
| Synonyms | 2210015O03Rik, 5031436O03RIK, dual specificity phosphatase 3, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related), LOC100502991, RGD1560049, T-DSP11, VHR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dusp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- receptor signaling protein tyrosine kinase inhibitor activity
- protein tyrosine/serine/threonine phosphatase
- protein-tyrosine-phoshatase
- phosphoprotein phosphatase
- PTP_DSP_cys
- protein binding
- Dual specificity phosphatase, catalytic domain
- cytoskeletal protein binding
- MAP kinase phosphatase
- receptor tyrosine kinase binding
- protein phosphatase
- phosphatase
Pathways
Biological processes and signaling networks where the Dusp3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neonatal late-onset sepsis
- hypothermia
role in cell
- migration
- activation
- phosphorylation in
- quantity
- mitochondrial respiration in
- motility
- assembly
- disassembly
- viral entry
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- immunological synapses
- cytosol
- nucleoplasm
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dusp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
- negative regulation of JNK cascade
- negative regulation of epidermal growth factor receptor signaling pathway
- positive regulation of mitotic cell cycle
- regulation of focal adhesion assembly
- negative regulation of T cell receptor signaling pathway
- negative regulation of ERK1 and ERK2 cascade
- cellular response to epidermal growth factor stimulus
- negative regulation of chemotaxis
- negative regulation of T cell activation
- dephosphorylation
- peptidyl-tyrosine dephosphorylation
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- MAP kinase phosphatase activity
- protein binding
- protein tyrosine phosphatase activity
- phosphatase activity
- cytoskeletal protein binding
- receptor tyrosine kinase binding
- myosin phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity