Crtc1 Gene Summary [Mouse]
Predicted to enable cAMP response element binding protein binding activity and transcription coactivator activity. Involved in entrainment of circadian clock by photoperiod and positive regulation of CREB transcription factor activity. Acts upstream of or within several processes, including memory; negative regulation of membrane hyperpolarization; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in limb and limb mesenchyme. Used to study major depressive disorder. Orthologous to human CRTC1 (CREB regulated transcription coactivator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crtc1 |
| Official Name | CREB regulated transcription coactivator 1 [Source:MGI Symbol;Acc:MGI:2142523] |
| Ensembl ID | ENSMUSG00000003575 |
| Bio databases IDs | |
| Aliases | CREB regulated transcription coactivator 1 |
| Synonyms | AI413414, CREB regulated transcription coactivator 1, Mam-2, MAML2, MECT1, mKIAA0616, R74955, TORC-1, WAMTP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crtc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transducer of regulated CREB activity middle domain
- transcription regulator
- cAMP response element binding protein binding
- Transducer of regulated CREB activity, C terminus
- coiled-coil domain
- protein binding
- Transducer of regulated CREB activity, N terminus
- phosphorylation site
- CREB binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
- cardiovascular disorder
- obesity
- esophageal adenocarcinoma
- esophageal carcinoma formation
- gastroesophageal reflux
- Barrett syndrome
role in cell
- expression in
- colony formation
- activation in
- proliferation
- growth
- transactivation in
- development
- cellular respiration in
- molecular cleavage in
- hyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
- chromatin
- perikaryon
- axons
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crtc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- rhythmic process
- entrainment of circadian clock by photoperiod
- energy homeostasis
- positive regulation of CREB transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- memory
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding protein binding
- protein binding