Map3k1 Gene Summary [Mouse]
Enables JUN kinase kinase kinase activity; MAP kinase kinase activity; and cytoskeletal protein binding activity. Involved in positive regulation of JUN kinase activity. Acts upstream of or within several processes, including eyelid development in camera-type eye; positive regulation of actin filament polymerization; and transforming growth factor beta receptor signaling pathway. Part of filamentous actin. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6; breast cancer; gastrointestinal system cancer (multiple); and lung non-small cell carcinoma. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map3k1 |
| Official Name | mitogen-activated protein kinase kinase kinase 1 [Source:MGI Symbol;Acc:MGI:1346872] |
| Ensembl ID | ENSMUSG00000021754 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 1 |
| Synonyms | LOC100912399, MAPK, MAPKKK1, MEKK, MEKK 1, MEK KINASE, MEK KINASE 1, mitogen-activated protein kinase kinase kinase 1, Raf, SRXY6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map3k1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- ATP-binding domain
- caspase cleavage site
- Protein kinase domain
- Sh3 domain binding motif
- cytoskeletal protein binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Tyrosine kinase, catalytic domain
- sphingolipid binding
- Protein kinase (unclassified specificity)
- protein kinase binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- JUN kinase kinase kinase
- JUN kinase binding
- Ring finger domain
- protein binding
- MAP kinase kinase kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- MAP kinase kinase
- kinase domain
- TOG-like domain
- binding protein
- Protein Kinases, catalytic domain
- ubiquitin-protein transferase activity
- RING-H2 zinc finger domain
Pathways
Biological processes and signaling networks where the Map3k1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- Ceramide Signaling
- EGF Signaling
- FGF Signaling
- Glucocorticoid Receptor Signaling
- HGF Signaling
- IL-1 Signaling
- Natural Killer Cell Signaling
- NF-κB Activation by Viruses
- NF-κB Signaling
- NGF Signaling
- PDGF Signaling
- Protein Kinase A Signaling
- Rac Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Renin-Angiotensin Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
- Type II Diabetes Mellitus Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- epithelial cancer
- congestive heart failure
- 46,XY sex reversal type 6
- serous ovarian adenocarcinoma
- serous ovarian cancer
- hereditary disorder
- prostatic carcinoma
role in cell
- expression in
- adhesion
- phosphorylation in
- apoptosis
- formation
- chemotaxis
- invasion by
- growth
- activation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- actin filaments
- intercellular junctions
- cytosol
- membrane ruffles
- cortical actin filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map3k1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- cellular response to mechanical stimulus
- Fc-epsilon receptor signaling pathway
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- zinc ion binding
- protein binding
- protein kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity