Slc1a6 Gene Summary [Mouse]
Enables L-glutamate transmembrane transporter activity. Acts upstream of or within L-glutamate transmembrane transport; establishment of localization in cell; and regulation of membrane potential. Located in Golgi apparatus and membrane. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human SLC1A6 (solute carrier family 1 member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc1a6 |
| Official Name | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 [Source:MGI Symbol;Acc:MGI:1096331] |
| Ensembl ID | ENSMUSG00000005357 |
| Bio databases IDs | |
| Aliases | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 |
| Synonyms | Eaac4, EAAT4, solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6, solute carrier family 1 member 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc1a6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium:dicarboxylate symporter family
- glutamate transporter
- aspartate transporter
- glutamate:sodium symporter
- TcyP
- high-affinity glutamate transporter
- transporter
- anion transporter
Pathways
Biological processes and signaling networks where the Slc1a6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- amyotrophic lateral sclerosis
- cervical spondylotic myelopathy
- spinocerebellar ataxia type 2
- Huntington disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- major depression
- neuromuscular disease
- social anxiety disorder
regulates
- L-glutamic acid
- L-aspartic acid
- ion
- neurotransmitter
role in cell
- transmembrane potential
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- intermediate filament cytoskeleton
- intracellular membranes
- cellular membrane
- Golgi Apparatus
- presynaptic membrane
- postsynaptic membrane
- dendritic spines
- synapse
- multivesicular bodies
- detergent insoluble microdomains
- perikaryon
- dendrites
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc1a6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurotransmitter transport
- ion transport
- regulation of membrane potential
- neurotransmitter uptake
- synaptic transmission
- neutral amino acid transport
- L-glutamate transport
- establishment of localization in cell
- aspartate transport
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- intermediate filament cytoskeleton
- membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- neutral amino acid transmembrane transporter activity
- L-aspartate transmembrane transporter activity
- high-affinity glutamate transmembrane transporter activity
- glutamate:sodium symporter activity
- L-glutamate transmembrane transporter activity