Pikfyve Gene Summary [Mouse]
Enables phosphatidylinositol kinase activity; protein serine/threonine kinase activity; and zinc ion binding activity. Involved in several processes, including neutrophil chemotaxis; phosphatidylinositol metabolic process; and vesicle organization. Acts upstream of or within myelin assembly. Located in several cellular components, including cell-cell junction; perinuclear region of cytoplasm; and vesicle membrane. Is expressed in several structures, including brain; genitourinary system; integumental system; limb; and skeleton. Used to study Crohn's disease. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pikfyve |
| Official Name | phosphoinositide kinase, FYVE type zinc finger containing [Source:MGI Symbol;Acc:MGI:1335106] |
| Ensembl ID | ENSMUSG00000025949 |
| Bio databases IDs | |
| Aliases | phosphoinositide kinase, FYVE type zinc finger containing |
| Synonyms | 5230400C17RIK, CFD, FAB1, HEL37, KIAA0981, p235, phosphoinositide kinase, FYVE-type zinc finger containing, PI5K, PIP5K, PIP5K3, Pipk5k3, PipkIII, Type III PI 5-kinase, ZFYVE29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pikfyve often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- FYVE zinc finger
- protein serine/threonine kinase
- lipid kinase
- catalytic domain
- Phosphatidylinositol-4-phosphate 5-Kinase
- protein binding
- kinase
- FYVE domain like superfamily
- DEP
- kinase domain
- Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
- zinc ion binding
- Protein present in Fab1, YOTB, Vac1, and EEA1
- alcohol group acceptor phosphotransferase
- phosphatase
- PHD finger superfamily
- 1-phosphatidylinositol-3-phosphate 5-kinase
- chaperonin_like
- 1-phosphatidylinositol-4-phosphate 5-kinase
Pathways
Biological processes and signaling networks where the Pikfyve gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pneumonitis
- fleck corneal dystrophy
- Hutchinson-Gilford progeria syndrome
- rotator cuff injury
- asthma
- hepatosplenomegaly
regulated by
- FIG4
- insulin
- wortmannin
- AMPK
- INS
- SB203580
- Sb202190
- diphtheria toxin
- GF 120918
- dexamethasone
role in cell
- thickness
- expression in
- phosphorylation in
- production in
- invasiveness
- proliferation
- activation in
- molecular cleavage in
- maturation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- low-density microsomal fraction
- membrane fraction
- cytoskeleton
- cell periphery
- perinuclear region
- intracellular membranes
- cellular membrane
- Plasma Membrane
- endosomes
- intercellular junctions
- cytosol
- vesicle membrane
- Golgi membrane
- endosomal membrane
- early endosomes
- late endosomes
- cytoplasmic vesicles
- membrane rafts
- Golgi vesicles
- phagosomes
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pikfyve gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol-3-phosphate biosynthetic process
- phagosome-lysosome fusion
- phagosome maturation
- phosphatidylinositol biosynthetic process
- retrograde transport, endosome to Golgi
- protein targeting to membrane
- receptor-mediated endocytosis
- melanosome organization
- viral entry into host cell via receptor-mediated endocytosis
- regulation of autophagic vacuole assembly
- neutrophil chemotaxis
- myelin assembly
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- protein localization to nucleus
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- cell-cell junction
- perinuclear region of cytoplasm
- vesicle membrane
- membrane raft
- cytosol
- phagocytic vesicle membrane
- cytoplasmic vesicle
- Golgi membrane
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
- ATP binding
- zinc ion binding
- 1-phosphatidylinositol-3-phosphate 5-kinase activity
- protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase activity
- protein serine/threonine kinase activity
- 1-phosphatidylinositol-5-kinase activity