Asf1b Gene Summary [Mouse]
Enables histone binding activity and histone chaperone activity. Acts upstream of or within blastocyst hatching and nucleosome assembly. Located in chromatin. Is expressed in several structures, including central nervous system; cranium; ear; genitourinary system; and retina. Orthologous to human ASF1B (anti-silencing function 1B histone chaperone). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asf1b |
| Official Name | anti-silencing function 1B histone chaperone [Source:MGI Symbol;Acc:MGI:1914179] |
| Ensembl ID | ENSMUSG00000005470 |
| Bio databases IDs | |
| Aliases | anti-silencing function 1B histone chaperone |
| Synonyms | 1700003K02Rik, anti-silencing function 1B histone chaperone, CIA-II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Asf1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- protein binding
- ASF1 like histone chaperone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- organismal death
- breast cancer
- hepatocellular carcinoma
- liver cancer
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
- B cell cancer
- acute myeloid leukemia
- epithelial uterine cancer
regulates
- ASF1A
- plasmid
role in cell
- expression in
- quantity
- assembly
- fusion
- fitness
- fusion in
- olaparib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Asf1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- blastocyst hatching
- cell differentiation
- nucleosome assembly
- DNA replication-dependent nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding